一、个人简介
韩文博,男,1985年生,陕西宝鸡人,理学博士,副教授,硕士生导师。
二、工作经历
2017/3 - 至今,必赢官网,必赢官网
2014/6 - 2016/12,南京大学,博士后,合作导师:谭仁祥
三、受教育经历
2011/9 - 2014/6,南京大学生物学专业,博士,导师:谭仁祥
2008/9 - 2011/6,南京大学微生物与生化药学,硕士,导师:谭仁祥
2004/9 - 2008/6,湖南农业大学,生物工程,学士
四、研究方向
1. 特境微生物(包括植物内生菌、昆虫共生菌和海洋微生物等)产生的结构新颖、活性显著的天然产物发现与结构鉴定。
2. 结构独特的活性天然产物生物合成过程研究。
五、科研项目
1. 国家自然科学基金青年基金项目(21702169)。
2. 陕西省自然科学基础研究计划青年项目(2018JQ2009)
六、承担课程
《天然产物化学》、《天然产物的结构解析》(研究生)
七、主要科研成果与学术论文
1. Yi Jie Zhai, Guang Ming Huo, Qiang Zhang, Ding Li, Da Cheng Wang, Jian Zhao Qi, Wen Bo Han,* Jin Ming Gao.* Phaeosphaones: Tyrosinase Inhibitory Thiodiketopiperazines from an Endophytic Fungus Phaeosphaeria fuckelii. J. Nat. Prod. 2020, 83, 1592–1597.
2. Wen Bo Han, Guang Yi Wang, Jiang Jiang Tang, Wen Ji Wang, Han Liu, Roberto R. Gil, Armando Navarro-Vázquez, Xinxiang Lei,* Jin Ming Gao.* Herpotrichones A and B, Two Intermolecular [4+2] Adducts with Anti-Neuroinflammatory Activity from a Herpotrichia Species. Org. Lett. 2020, 22, 405−409.
3. Guang Zhi Dai#, Wen Bo Han#, Ya Ning Mei, Kuang Xu, Rui Hua Jiao, Hui Ming Ge, Ren Xiang Tan.* Pyridoxal-5'-phosphate-dependent Bifunctional Enzyme Catalyzed Biosynthesis of Indolizidine Alkaloids in Fungi. Proc. Natl. Acad. Sci. U S A. 2020, 117, 1174−1180 (共同第一作者).
4. Wen Bo Han, Yi Jie Zhai, Yuqi Gao, Hui-Yi Zhou, Jian Xiao, Gennaro Pescitelli, Jin Ming Gao.* Cytochalasins and an Abietane-Type Diterpenoid with Allelopathic Activities from the Endophytic Fungus Xylaria Species. J. Agric. Food Chem. 2019, 67, 3643−3650.
5. Wen Bo Han, He Li, Hui Yi Zhou, Jia Meng, Jin Ming Gao, Jun Mian Tian,* An Ling Zhang.* Chaetolactone, a Skeletally New Cyclopentenone from Chaetomium sp. C521. Nat. Prod. Commun. 2018, 13, 879−881.
6. Wen Bo Han, Ai Hua Zhang, Xin Zhao Deng, Xinxiang Lei, Ren Xiang Tan.* Curindolizine, an Anti-inflammatory Agent Assembled via Michael Addition of Pyrrole Alkaloids inside Fungal Cells. Org. Lett. 2016, 18, 1816−1819.
7. Wen Bo Han, Huan Dou,Wei Hua Yuan,Wei Gong,Ya Yi Hou,Seik Weng Ng, Ren Xiang Tan.* Meroterpenes with Toll-Like Receptor 3 Regulating Activity from the Endophytic Fungus Guignardia mangiferae. Planta Med. 2015, 81, 145–151.
8. Wen Bo Han, Yan Hua Lu, Ai Hua Zhang, Gao Fei Zhang, Ya Ning Mei, Nan Jiang, Xinxiang Lei, Yong Chun Song, Seik Weng Ng, Ren Xiang Tan.* Curvulamine, a New Antibacterial Alkaloid Incorporating Two Undescribed Units from a Curvularia Species. Org. Lett. 2014, 16, 5366−5369.
八、联系方式
通讯地址:必赢官网理科楼E214
邮编:712100
邮箱:wbhan@nwafu.edu.cn